I believe praying for God to remove your major depressive disorder is about as effective as praying for Him to remove your diabetes. It may work – God can do anything, after all. I seriously doubt it is likely, however. With depression, it may even have a deleterious effect. If or when prayer doesn’t work, you are likely to blame yourself. The last thing a depressed person needs is more self-blame for situations beyond his or her control. As with diabetes, there are more effective means to treat depression than simply praying for God to take it away. If you have major depression due to faulty brain chemicals, maybe, just maybe God made you that way on purpose. I believe God wants us to love and help each other. Perhaps a better thing to pray for is that God reveal to you how to use your experience to help others who suffer. Does God want us to be happy? I can’t say. But I do recall that there where times when even Jesus was severely depressed [Matthew 26:38].
The praying which makes a prayerful ministry is not a little praying put in as we put flavor to give it a pleasant smack, but the praying must be in the body, and form the blood and bones. Prayer is no petty duty, put into a corner; no piecemeal performance made out of the fragments of time which have been snatched from business and other engagements of life; but it means that the best of our time, the heart of our time and strength must be given.